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List of publications on a keyword: «EMI»

  • Дидактическая игра как средство формирования фонематического восприятия у старших дошкольников со стертой дизартрией

    Conference Paper
    Defectology and Education Today: Fundamental and Applied Research
    Authors:
    Milena I. Paskhalidi, Elena A. Shumilova
    Work direction:
    Varia (принимаются материалы по другим направлениям, соответствующим теме конференции)
    Abstract:
    The article discusses the problem of developing phonemic perception in older preschool children with mild dysarthria through the use of didactic games. It provides an analysis of theoretical approaches to understanding the specific features of phonemic processes in this form of speech pathology. The article substantiates the importance of using game methods in speech therapy for preschool children with dysarthric disorders. It describes the directions and stages of developing phonemic perception through didactic games. The article presents the results of the practical application of game technologies in speech therapy.
    Keywords:
    speech therapy correction, senior preschool age, game technologies, phonemic hearing, phonemic perception, didactic game, and mild dysarthria

  • Kokshansky and Bondyuzhsky chemical plants in 1921. (based on official reports)

    Conference Paper
    Relevant problems of modern science and education
    Author:
    German I. Fan iung
    Work direction:
    Актуальные проблемы и современные тренды государственного и муниципального управления, развития экономической системы и правовых аспектов в России и за рубежом
    Abstract:
    The purpose of our research is to provide a brief and superficial analysis of the state of the two former Ushkov chemical factories, Kokshansky and Bondyuzhsky, in 1921, three years after their nationalization and a year before the end of the Russian Civil War. The author demonstrated the number of workers and employees, the range and volume of products produced, listed the main and auxiliary production areas, described the energy equipment of the Bondyuzhsky plant, etc. The analysis of archival materials revealed a sharp decrease in the real wages of workers and employees and the suspension of the Kokshansky plant's operations in June 1921.
    Keywords:
    Keywords: Russian chemical industry, Russian Civil War, Kokshansky and Bondyuzhsky chemical plants
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  • Integration of ESG pricniples in business valuation on the example of Iberdrola S.A

    Conference Paper
    Relevant problems of modern science and education
    Authors:
    Nadezhda O. Tiapkina, Iuliia S. Tsertseil
    Work direction:
    Актуальные проблемы и современные тренды государственного и муниципального управления, развития экономической системы и правовых аспектов в России и за рубежом
    Abstract:
    The article discusses the issue of integration of ESG factors into business valuation practices, with a focus on the ESG premium exemplified by Iberdrola S.A. Through discounted cash flow analysis incorporating WACC adjustments, it demonstrates how superior ESG performance generates a negative premium, reflecting reduced systemic risk due to leadership in renewable energy and consistently top-tier sustainability ratings. This study highlights methodological considerations, such as the need for economic constraints and scenario validation, to address model sensitivities. Findings underscore ESG’s pivotal role in enhancing long-term value creation and competitiveness for energy sector firms.
    Keywords:
    renewable energy, ESG premium, business valuation, WACC adjustment, DCF model, systematic risk, sustainability ratings
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  • CROSS-CULTURAL ADAPTATION OF EDUCATIONAL PROGRAMS: EXPERIENCE IN TRAINING CHINESE VOCALISTS IN THE RUSSIAN PEDAGOGICAL TRADITION

    Conference Paper
    Socio-Pedagogical Issues of Education and Upbringing
    Author:
    Tsze U
    Work direction:
    Содержание и технологии профессионального образования
    Abstract:
    The article is devoted to the study of the process of cross-cultural adaptation of educational programs of the vocal profile in the training of Chinese students in Russian pedagogical universities. The multilevel structure of intercultural interaction is considered, including linguistic, methodological, physiological and cultural-aesthetic components. The language barriers of articulation nature, caused by the phonetic features of the Chinese language, are analyzed. The directions of adaptation of the Russian vocal school are characterized, taking into account the specifics of the students’ vocal apparatus. The productivity of the integrative approach, combining the Russian academic tradition and Chinese musical aesthetics, is substantiated.
    Keywords:
    foreign students, pedagogical education, intercultural interaction, music, Chinese students, vocal education, cross-cultural adaptation, Russian vocal school, professional competence of a vocalist, academic singing
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  • ВЛИЯНИЕ ОСОБЕННОСТЕЙ НАЛОГООБЛОЖЕНИЯ СУБЪЕКТОВ МАЛОГО И СРЕДНЕГО ПРЕДПРИНИМАТЕЛЬСТВА НА ИНВЕСТИЦИОННУЮ АКТИВНОСТЬ В ВЫСОКОТЕХНОЛОГИЧНЫХ СЕКТОРАХ ЭКОНОМИКИ

    Conference Paper
    The socio-economic landscape of the region: people and digital transformation
    Authors:
    Guzel M. Guseinova, Anastasiia A. Bykova, Sofiia M. Moisieva
    Work direction:
    Цифровая экономика и новые бизнес-модели региона
    Abstract:
    The article examines the relationship between tax instruments for supporting small and medium-sized enterprises and the strategic goal of achieving technological leadership as part of the country's national development goals until 2030. The authors highlight the issue of insufficient investment in innovation due to the inefficient use of existing tax incentives. Based on the results of the study, it is concluded that it is necessary to overcome systemic barriers, such as high insurance contributions, other non-tax payments, and difficulties in navigating regional support programs, in order to strengthen the role of tax policy as a catalyst for technological development.
    Keywords:
    small and medium-sized enterprises, investment activity, technological leadership, special tax regimes, high-tech sectors, income tax, regional benefits, national goals, insurance premiums, and non-tax payments
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  • Assessment of the Academic Success of Students at a Teaching University in Terms of Their Relationship with the Results of the Uniform State Examination

    Research Article
    Development of education Volume 9 No 1
    Authors:
    Ekaterina A. Ilyina, Svetlana V. Ilina, Larisa G. Vasilyeva, Svetlana V. Grigoreva
    Work direction:
    Pedagogy and Modern Education
    Abstract:
    This article presents an empirical assessment of the predictive validity of the Unified State Exam (USE) results for the academic performance of students majoring in the social sciences and humanities at the Chuvash State Pedagogical University named after I. Ya. Yakovlev for 2021–2025. The aim of the study is to quantify the relationship between the average USE score in specialized subjects and academic performance, taking into account the form of funding and specialized features. Official data on the USE results of school graduates in Chuvashia, monitoring of educational trajectories, and intra-university statistics were used. Spearman correlation analysis, the Mann-Whitney U-test, and dynamic analysis were applied. It was found that an average USE score ≥70 correlates with high-quality academic performance in subject-oriented humanities programs (ρ = 0.38–0.42, p < 0.001). A significant difference in academic performance was found between state-funded and fee-paying students (r = 0.39–0.58), indicating the role of motivational factors. In creative profiles, no statistically significant relationship was found between the results of the Unified State Exam and academic performance (ρ < 0.15, p > 0.05). The results confirm the need for a differentiated approach to applicant selection and the development of support programs for them.
    Keywords:
    academic performance, Unified State Exam, correlation analysis, continuity of education, Chuvash State Pedagogical University named after I.Ya. Yakovlev, regional educational trajectories
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  • Ispol'zovanie neirosetei v sisteme obrazovaniia: preimushchestva i riski

    Conference Paper
    Current problems of communication: theory and practice
    Authors:
    Iurii A. Denisenko, Daniil F. Klimenko
    Work direction:
    Конвергентные коммуникации будущего: интеграция цифровой среды, нейронаук, искусственного интеллекта и новых медиа
    Abstract:
    Over the past three years, neural networks and other artificial intelligence (AI) technologies have become one of the most discussed topics in education, from school to university. This article examines the main uses of neural networks in the educational process, analyzing their key benefits (personalization, automation of everyday tasks, expanding access to knowledge) and risks (ethical issues, substitution of independent work, digital divide, unreliable information). Based on an analysis of modern scientific and educational literature, it shows how neural networks are changing education and what conditions are necessary for their safe and effective implementation. The research methods include analysis and synthesis of scientific literature, comparison of approaches by different authors, and practical examples.
    Keywords:
    education, information security, artificial intelligence, digitalization, neural networks, personalized learning, academic integrity
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  • The conceptual structure of the development of educational motivation through the construction of an individual educational trajectory based on the use of Internet technologies

    Book Chapter
    Issues of education and psychology
    Authors:
    Meiseria G. Akhmetvalieva, Nataliia G. Veliunskaia, Marina A. Koniaeva
    Work direction:
    Глава 2
    Abstract:
    Motivation for learning is one of the most crucial tools for building a high-quality education, an educational environment in which students learn to develop a strategy for their future life and responsibly build a self-development trajectory. A number of researchers note that creating models of such self-development trajectories for students remains a challenge; there are no developed guidelines for building their own educational path. The objective of this study is to examine the conceptual structure of developing academic motivation through the step-by-step development of an individual educational environment using modern digital technologies. Structural components are developed. At each stage (component), tasks are detailed and their content is described. In addition, in the event of incorrect task completion, correction strategies are identified.
    Keywords:
    motivation, students, digital technologies, individual educational trajectory, academic motivation, internet technologies, motives, extrinsic motives, intrinsic motives, professional knowledge
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  • Формирование исследовательских навыков у младших школьников в рамках предмета «Окружающий мир» в 1 классе

    Conference Paper
    Education, innovation, research as a resource for community development
    Author:
    Larisa V. Sokolova
    Work direction:
    Образовательный процесс в организациях общего и дополнительного образования
    Abstract:
    The formation of research skills in primary school students is an important pedagogical task, as research activities help to develop the ability to see problems, ask questions, formulate hypotheses, define concepts, etc. The subject "World around us" has the potential to form these skills: students conduct observations of the world around them, make assumptions, and explore the environment and objects.
    Keywords:
    educational process, Research activities, and academic research
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  • AI Assistants as Tutors: Ethical Boundaries for Using Neural Networks to Personalize Programming Education

    Conference Paper
    Education, innovation, research as a resource for community development
    Authors:
    Inna G. Iglinskaia, Anastasiia V. Petrakova
    Work direction:
    Использование нестандартных решений для повышения качества, доступности и эффективности образования
    Abstract:
    The article discusses the current problem of integrating artificial intelligence (AI), in particular, large language models (LLM), into the educational process of training specialists in the specialty 02/09/07 "Information Systems and Programming". The purpose of the study is to analyze the potential of AI assistants as personalized tutors to develop programming skills and identify the associated ethical risks and pedagogical limitations. Based on the analysis of modern literature and the author's practical experience, key dilemmas have been identified: the reliability of the generated code and explanations, the risk of intellectual dependence, issues of academic integrity and digital inequality. The article offers a model for the balanced use of AI assistants based on the principles of pedagogical support, the development of critical thinking and the formation of digital hygiene among students. It is concluded that AI is a powerful tool for improving the accessibility and effectivenes
    Keywords:
    pedagogical design, tutoring, ChatGPT, programming, AI ethics, academic integrity, artificial intelligence in education, learning personalization, large language models (LLM), and professional education
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  • Etiology of the emergence of cognitive interest in primary school students: structure, manifestations and pedagogical conditions for its formation

    Conference Paper
    Modern educational process: psychological and pedagogical support, educational strategies
    Authors:
    Anastasiia S. Golodniak, Ekaterina I. Karetnikova, Marina L. Sher
    Work direction:
    Психологические аспекты современного образования
    Abstract:
    The article explores the theoretical foundations of cognitive interest formation in primary school children. It examines the origins, internal structure, and developmental levels of this phenomenon within the framework of developmental psychology and pedagogy. Special attention is given to the specific ways cognitive interest manifests in students with disabilities, particularly those with intellectual impairments. Drawing on the works of G. I. Shchukina, L. S. Vygotsky and other scholars, the paper outlines key pedagogical conditions that foster and sustain cognitive motivation in inclusive educational settings. It is emphasized that cognitive interest serves not only as a driving force behind academic engagement but also as an indicator of harmonious personal development.
    Keywords:
    pedagogical conditions, motivation, inclusive education, children with disabilities, primary school age, cognitive interest, academic activity, etiology of interest
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  • Theoretical Approaches to the Development of Educational Models

    Review Article
    Development of education Volume 8 No 4
    Authors:
    Roman V. Demyanchuk, Tatiana A. Komarnitskaia
    Work direction:
    Pedagogy and Modern Education
    Abstract:
    The article discusses the theoretical foundations of designing educational models in the context of the transformation of modern education. The purpose of the study is to analyze the main approaches to the development of educational models. The methodological base uses the works of domestic and foreign researchers (A. M. Novikov, D. A. Novikov, L. S. Vygotsky, J. Piaget, J. Bruner, A. Bandura, G. Gardner, and others), as well as the principles of cognitive, constructivist, sociocultural, and systemic approaches. The methods of comparative theoretical analysis, conceptual modeling and generalization of scientific sources are applied. As a result of the research, the position is substantiated that the application of individual theoretical approaches in an isolated form limits the possibilities of designing educational models, while their integration within the framework of a systematic approach makes it possible to form an integrated and adaptive educational model. It is shown that the inclusion of sociocognitive mechanisms and consideration of multiple forms of intelligence are conditions for the practical feasibility of integrative educational models and their personalization. The practical significance of the research lies in the possibility of using the findings in the design of educational programs, digital educational environments and personalized learning technologies.
    Keywords:
    design, cognitive approach, systemic approach, educational model, constructivism, socio-cultural approach
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  • The Relationship Between Academic Resistance and Cognitive Activity of the Students of the Yelabuga Institute of Kazan (Volga Region) Federal University

    Research Article
    Development of education Volume 8 No 4
    Author:
    Tatyana N. Bochkareva
    Work direction:
    Pedagogy and Modern Education
    Abstract:
    The training of undergraduates in the pedagogical field (students of the second stage of higher education) includes not only the development of competencies enshrined in the federal state educational standard of higher education, but also the formation or consolidation of skills such as the ability to cope with extreme professional situations, flexibility in difficult situations, mobilization of moral and volitional efforts to achieve their goals, etc. The ability to succeed in school despite social barriers and difficulties, i.e. academic resistance reaches its greatest relevance by the time of graduate studies. Cognitive activity contributes to the most complete assimilation of educational information and the formation of professional competencies. Information about the relationship between academic resistance and cognitive activity of undergraduate students is the subject of this paper. In the course of the work, the following methods were used – the full version of the Scale of individual academic Resistance (adaptation of R. S. Zvyagintsev) and a method for diagnosing the motivation of learning and emotional attitude to learning (A. D. Andreeva, A. M. Prikhozhan). The study revealed the relationship between academic resilience and cognitive activity, as well as the greater influence of cognitive activity components on academic resilience.
    Keywords:
    cognitive activity, university, master's degree, academic resilience, resilience
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  • The Nizhny Novgorod Chemical Plant by Z.M. Persitz as the "flagship" of salolin production in pre-revolutionary Russia

    Conference Paper
    Relevant issues of management, economics and economic security
    Author:
    German I. Fan iung
    Work direction:
    Мировая и региональная экономика
    Abstract:
    In this article, an attempt is made to briefly and very superficially study the organization of the production of salolin on an industrial scale at the Nizhny Novgorod Chemical Plant of Z.M. Persitz in 1909-1912. The author reveals the relationship of chemistry and the chemical industry with industrial development. The importance of salolin, which acted as not only the most important raw material for various industries, but also was a socially significant product, at least at the beginning of the 20th century, is demonstrated. It is concluded that due to the successful development of the production of salolin, the Nizhny Novgorod Chemical Plant Z.M. Persitz has become one of the most advanced and high-tech industries of global importance.
    Keywords:
    Chemical industry of pre-revolutionary Russia, Nizhny Novgorod Chemical Plant by Z.M. Persitz, hydrogenation of fatty acids, Z.M. Persitz, V. Normann, M.V. Vilbushevich
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  • Systemic contradictions of financial support for regional development

    Book Chapter
    Development of the Russian socio-economic system: challenges and prospects
    Author:
    Irina N. Shvetsova
    Work direction:
    Глава 5
    Abstract:
    The chapter examines key systemic contradictions in the financial support of regional development under contemporary conditions, including the impact of geopolitical changes and sanction pressures on financial flows and instruments. It analyzes the formation, allocation, and effective use of budgetary resources at the regional level amid current economic challenges. Special attention is given to financial regulation mechanisms, risks, and constraints hindering balanced regional development. The chapter proposes ways to improve financial policy to enhance the resilience and balance of regional growth, as well as the integration of innovative financial instruments into regional financial management. A systemic approach is employed, combining material, procedural, and managerial components of financial support. Strategic objectives and mechanisms for their realization are analyzed to increase financial support effectiveness.
    Keywords:
    sustainable development, risks, regional development, financial instruments, financial policy, financial support, systemic contradictions, financial regulation
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  • Развитие взаимодействия страхового сектора с другими финансовыми институтами

    Conference Paper
    Law, Economics and Management
    Author:
    Marina V. Ilindeeva
    Work direction:
    Социально-экономическое развитие общества
    Abstract:
    This article explores the multifaceted interactions between the insurance sector, banking institutions, investment funds, and fintech companies, analyzing its role in strengthening the financial system and identifying barriers to effective integration. It addresses issues of information asymmetry, conflicts of interest, regulatory uncertainty, and technological incompatibility, and proposes mechanisms for overcoming them.
    Keywords:
    digitalization, Insurance sector, financial institutions, financial integration, systemic sustainability
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  • The level structure of teaching motivation

    Book Chapter
    Issues of education and psychology
    Author:
    Galina A. Glotova
    Work direction:
    Глава 4
    Abstract:
    This chapter discusses a three-level model of learning motivation, which includes the levels of general and academic emotional orientation, as well as the level of specific learning motives. The study used the following methods: «General Emotional Orientation» (Dodonov, 1978), «Academic Emotional Orientation» (Glotova, 2025), «Diagnostics of University Students’ and High School Students’ Learning Motivation» (Badmaeva, 2004), «Academic Motivation Scales» (Gordeeva, Sychev, Osin, 2014), «Comprehensive Assessment of Learning Motivation – Pilot Scales» (Glotova, Shipilova, 2025). The study, conducted using a Google form, was voluntarily and anonymously participated by 86 school students of grades 10–11 and college students. When processing data, correlation analysis (by Spearman) was used. The results of the study confirmed the hierarchical structure of learning motivation, which includes three levels with multiple significant correlations between them; despite the different names of the scales of three methods due to the theoretical and methodological preferences of the authors, a large number of significant correlations have been obtained between these scales; the scales of motives for subject activity in learning correlate more closely with each other than with the scales of communication motives, and vice versa, the scales of communication motives in learning correlate more closely with each other than with the scales of subject activity motives; the three levels of learning motivation are related to the categories of «activity», «actions» and «operations» of learning proposed by A.N. Leontiev (1975).
    Keywords:
    learning, learning motivation, general emotional orientation, academic emotional orientation, older teenagers
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  • EXISTENTIAL PORTRAIT OF V.I. LENIN IN RUSSIAN EMIGRANT LIT-ERATURE 1920S – 1930S

    Book Chapter
    Issues of education and psychology
    Author:
    Viacheslav A. Ermakov
    Work direction:
    Глава 13
    Abstract:
    The work recreates an existential portrait of V.I. Lenin based on the works of Russian emigrants. The psychological, social, political, religious and philosophical characteristics of V.I. Lenin's personality given by emigrants are studied. The historical context of the formation of Russian emigrants' evaluative views on the activities of V.I. Lenin is considered. The approaches of emigrants to demythologization of the historical image of V.I. Lenin are clarified. In the context of modern psychology, the interpretation of the analysis of the character of V.I. Lenin, carried out by emigrants, is considered. The system of accusations of Leninist Bolshevism by emigrants is reconstructed. The specificity of understanding of V.I. Lenin by emigrants as the main existential enemy of the Russian people and Russian Orthodox civilization is revealed. The continuity and development of the views of emigrants in modern studies of the phenomenology of the personality of V.I. Lenin is shown.
    Keywords:
    history of Russia, existential portrait, Lenin V, emigrant literature
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  • Low-carbon economics: challenges and perspectives

    Book Chapter
    Development of the Russian socio-economic system: challenges and prospects
    Author:
    Andrei V. Minakov
    Work direction:
    Глава 5
    Abstract:
    In the chapter presents the results of a studying the development of a low-carbon economy in Russia and developed countries. Nowadays developed countries are investing significant resources to boost energy transition, aiming to achieve carbon neutrality by 2050. In Russia the growth of greenhouse gas emissions continue, and, according to the target scenario for Russian economy, will continue until 2030. However, are implemented important measures to develop low carbon economy: renewable energy sources, financial support, market of emission quotas. Is increasing the number of implemented «green» projects. So Russia will be able to reduce greenhouse gas emissions by 80% to the 1990 level. Achieved results can be used in improving the socio-economic development based on the concept of a low-carbon economy.
    Keywords:
    environment, greenhouse gas emissions, renewable energy, carbon neutrality, low carbon economy
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  • Problems of implementation of the preventive function of modern legal procedural policy

    Conference Paper
    Strategies of Sustainable Development: Social, Law and External-economic Aspects
    Author:
    Eduard E. Isaev
    Work direction:
    Актуальные вопросы юриспруденции
    Abstract:
    The article examines current issues of implementing the preventive function of modern legal procedural policy. The role of this function in preventing marginal behavior, extremism and judicial errors is analyzed. Particular attention is paid to a systemic approach to counteracting destructive phenomena, including the interaction of law enforcement agencies, educational institutions and public organizations. Aspects of rehabilitation of the innocent are considered, including ideal compensation as a form of public recognition of error. The need for interdisciplinary strategies to ensure stability, legality and citizens' trust in the legal system is shown.
    Keywords:
    legal procedural policy, preventive function, marginal behavior, systemic approach
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  • A foreign language as a means of training specialists in the process of continuing education

    Conference Paper
    The Topical Issues of the Humanities and Social Sciences
    Author:
    Milana V. Rovenskaia
    Work direction:
    Современные гуманитарные науки и проблемы языкознания
    Abstract:
    The article examines the concept of continuing education in the context of modern socio-economic changes and technological development. The main focus is on the role of continuing education in training professionals who are able to adapt to rapidly changing labor market conditions and requirements. The impact of technological progress on society and the education system is analyzed, and the main functions of continuing education are highlighted: professional, social and personal. The work emphasizes the importance of developing students' independence, responsibility and determination in the process of continuous professional education. The necessity of updating the knowledge and skills of specialists in various fields is emphasized in order to maintain competitiveness. The article considers the role of learning foreign languages in professional training and their impact on the expansion of human opportunities in education, work and communication. Theoretical research methods were used to analyze the problem, including analysis of scientific publications and official documents, such as the Concept of Technological Development of Russia until 2030. As a result of the analysis, the key competencies necessary for successful professional, family and social life in the context of the transformation of the socio-economic sphere have been identified. Among them are computer skills and foreign languages, technological literacy, entrepreneurial skills and social skills. It was also noted that Nizhnevartovsk State University (NVSU) pays special attention to the study of English in the framework of the program "English for academic mobility". It is emphasized that academic mobility contributes to the expansion of educational horizons, the formation of intercultural competencies and the creation of employment potential for graduates.
    Keywords:
    foreign language, competitiveness, continuing education, academic mobility, English, technological development, modernization of education, intercultural competencies
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  • Development of dialogic speech skills in senior preschool children with phonetic-phonemic speech underdevelopment

    Conference Paper
    Psychological and Pedagogical Research – Tula Region
    Authors:
    Regina V. Eivazova, Irina B. Kozina
    Work direction:
    Security of educational activities during quarantine measures
    Abstract:
    The article presents the results of studying dialogic speech in senior preschool children with phonetic-phonemic speech underdevelopment. The authors of the article describe in detail the identified deficiencies in the development of dialogic speech, and also consider the main areas of correctional and developmental work of a speech therapist.
    Keywords:
    dialogue, senior preschoolers, preschool children, speech disorders, dialogic speech, phonetic-phonemic speech underdevelopment
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  • The effects of the COVID-19 pandemic on the psychosomatic state of children and adolescents

    Conference Paper
    The health of participants in the educational process: modern challenges and solutions
    Authors:
    Anna S. Vavshko, Iuliia G. Aseeva, Tatiana S. Belitskaia, Ashot A. Pogosian
    Work direction:
    Психическое и психологическое здоровье личности в изменяющемся мире
    Abstract:
    The COVID-19 pandemic has led to a global crisis affecting not only the physical but also the mental health of people, including children and adolescents. The article examines the impact of the pandemic on the psychosomatic state of young people, including the effects of isolation, distance learning, and fear of infection. It is noted that children at a vulnerable stage of development are more susceptible to negative effects on mental health. The main factors contributing to mental well-being, such as parental support, physical activity and social support, as well as harmful factors such as emotional reactivity and excessive information, are considered. The article highlights the importance of additional study of the long-term consequences and the development of rehabilitation methods for children who have suffered COVID-19.
    Keywords:
    stress, mental health, COVID-19 pandemic, rehabilitation, psychosomatic condition, children and adolescents, social isolation, psychopathology, psychoemotional well-being
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  • Autoantibodies and Cytokines in the Pathogenesis of Systemic Sclerosis: From Molecular Mechanisms to Clinical Therapy

    Conference Paper
    Fundamental and applied research for key propriety areas of bioecology and biotechnology
    Authors:
    Iuliia A. Kudrova, Sofia V. Erzukova
    Work direction:
    Биохимия. Биомедицинские технологии
    Abstract:
    Systemic sclerosis (SSc) is a rare connective tissue disorder characterized by vasculopathy, abnormal immune system activation with autoantibody production, and fibrosis development. This article reviews current therapeutic approaches for SSc, including the use of methotrexate, tofacitinib, and ziritaxestat. It discusses the role of interleukin-17 (IL-17) in disease pathogenesis and the potential of brodalumab, an IL-17 inhibitor, in reducing the modified Rodnan skin score (mRSS) and skin thickness. The study aims to systematically analyze the pathogenesis, clinical manifestations, and dermatological changes associated with SSc. Conclusions: Investigating the role of autoantibodies and cytokines in the pathogenesis of systemic sclerosis reveals the molecular mechanisms underlying fibrosis and chronic inflammation. Understanding these processes enables the development of therapeutic strategies, including the suppression of pro-inflammatory cytokines and blockade of autoantibodies.
    Keywords:
    systemic sclerosis, biomarker, topoisomerase, Rodnan skin score, autoantibodies
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  • Some aspects of extremist crimes

    Conference Paper
    Law, Economics and Management
    Author:
    Saida V. Kaipbekova
    Work direction:
    Актуальные вопросы юриспруденции
    Abstract:
    The work is devoted to the analysis of extremist crimes in the Russian Federation, including the legal basis, the subjects of crimes and their consequences for society.
    Keywords:
    crime, Extremism, crimes of an extremist nature
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