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Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis

Proceeding
DOI: 10.31483/r-102302
Open Access
All-Russian scientific conference with International Participation «Fundamental and applied research for key propriety areas of bioecology and biotechnology»
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Published in:
All-Russian scientific conference with International Participation «Fundamental and applied research for key propriety areas of bioecology and biotechnology»
Authors:
Vera R. Lezhniova 1 , Ekaterina V. Martynova 1 , Timur I. Khaibullin 2 , Ilnur I. Salafutdinov 1 , Mariia I. Markelova 1 , Aleksandr V. Laikov 1 , Leonid V. Lopukhov 1 , Svetlana F. Khaibullina 1
Work direction:
Биохимия и токсикология (биохимические, иммунологические, токсикологические исследования)
Pages:
213-220
Received: 5 May 2022

Rating:
Article accesses:
1099
Published in:
РИНЦ
1 Kazan Federal University
2 GAUZ "Respublikanskii klinicheskii nevrologicheskii tsentr"
For citation:
Lezhniova V. R., Martynova E. V., Khaibullin T. I., Salafutdinov I. I., Markelova M. I., Laikov A. V., Lopukhov L. V., & Khaibullina S. F. (2022). Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis. Fundamental and applied research for key propriety areas of bioecology and biotechnology, 213-220. Чебоксары: PH "Sreda". https://doi.org/10.31483/r-102302

Abstract

Multiple sclerosis (MS) is a chronic debilitating disease of unknown etiology. The disease has a seasonal exacerbation of clinical symptoms, which are frequently described in spring and summer. However, the mechanisms of such seasonal exacerbations remain unknown. In this study, we used targeted metabolomics analysis of serum samples using LC-MC/MC to determine seasonal changes in metabolites. We have found changes in multiple metabolites which differed depending on season. The ceramides, belonging to the sphingolipid pathway, were found activated in spring-summer (SS) and fall-winter (FW) MS, suggesting their central role in disease pathogenesis. Our identification of ceramide activation suggests a mechanism of neuron damage in MS which could be further investigated as therapeutic targets.

Acknowledgments

Работа выполнена в рамках Программы стратегического академического лидерства Казанского (Приволжского) федерального университета.

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